9rql

GT-C O-Mannosyltransferase TMEM260 incubated with Far-P-Man

spinqualitylabelsall models 9rql, resolution 2.65Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9rql is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.65Å Ligands: A1JKY, NAG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease TM260_HUMAN Structural heart defects-renal anomalies syndrome. The disease is caused by variants affecting the gene represented in this entry. Function TM260_HUMAN O-mannosyl-transferase that transfers mannosyl residues to the hydroxyl group of serine or threonine residues of proteins (PubMed:37186866). Specifically glycosylates the IPT/TIG domain of target proteins, such as MET and MST1R/RON (PubMed:37186866). TMEM260-mediated O-mannosylated residues are composed of single mannose glycans that are not elongated or modified (PubMed:37186866).

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