| Structural highlights
9ru6 is a 10 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Method: | Electron Microscopy, Resolution 2.64Å |
| Ligands: | 1MA, 2MG, 5F0, 5MC, 5MU, ACE, ATP, B8T, FES, GDP, K, MA6, MG, NAD, OMG, OMU, PSU, SPD, THC, VOL, ZN |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Disease
TACO1_HUMAN The disease is caused by variants affecting the gene represented in this entry.
Function
TACO1_HUMAN Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1.[1]
References
- ↑ Weraarpachai W, Antonicka H, Sasarman F, Seeger J, Schrank B, Kolesar JE, Lochmüller H, Chevrette M, Kaufman BA, Horvath R, Shoubridge EA. Mutation in TACO1, encoding a translational activator of COX I, results in cytochrome c oxidase deficiency and late-onset Leigh syndrome. Nat Genet. 2009 Jul;41(7):833-7. PMID:19503089 doi:10.1038/ng.390
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