Structural highlights
Function
ENCAP_RHORT Shell component of a type 1 encapsulin nanocompartment. Assembles into proteinaceous icosahedral shells 24 nm in diameter in the presence and absence of its ferritin cargo protein. The center of cargo-loaded nanocompartments is loaded with iron. The empty encapsulin nanocompartment sequesters about 2200 Fe ions while the cargo-loaded nanocompartment can maximally sequester about 4150 Fe ions. Does not have any detectable ferroxidase activity.[1] [2]
References
- ↑ He D, Hughes S, Vanden-Hehir S, Georgiev A, Altenbach K, Tarrant E, Mackay CL, Waldron KJ, Clarke DJ, Marles-Wright J. Structural characterization of encapsulated ferritin provides insight into iron storage in bacterial nanocompartments. Elife. 2016 Aug 16;5. pii: e18972. doi: 10.7554/eLife.18972. PMID:27529188 doi:https://dx.doi.org/10.7554/eLife.18972
- ↑ Piergentili C, Ross J, He D, Gallagher KJ, Stanley WA, Adam L, Mackay CL, Basle A, Waldron KJ, Clarke DJ, Marles-Wright J. Dissecting the structural and functional roles of a putative metal entry site in encapsulated ferritins. J Biol Chem. 2020 Sep 2. pii: RA120.014502. doi: 10.1074/jbc.RA120.014502. PMID:32878987 doi:https://dx.doi.org/10.1074/jbc.RA120.014502