9s4u

CgCdr1 in complex with Itraconazole, ATP and ADP-Mg

spinqualitylabelsall models 9s4u, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9s4u is a 1 chain structure with sequence from Candida glabrata. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3Å Ligands: 1YN, ADP, ATP, ERG, LYS, MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function CDR1_CANGA Pleiotropic ABC efflux transporter that transports and confers resistance to structurally and functionally unrelated compounds including rhodamine 6G, Nile red, caspofungin, cycloheximide, or azoles such as fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole, and isavuconazole (PubMed:10543759, PubMed:12244114, PubMed:15105111, PubMed:15105136, PubMed:15388433, PubMed:15498768, PubMed:16803598, PubMed:17581937, PubMed:18591262, PubMed:20038613, PubMed:20450660, PubMed:21134356, PubMed:21408004, PubMed:22788839, PubMed:26482310, PubMed:27486188, PubMed:29371812, PubMed:29784839). Chlorbromuron, itraconazole, yohimbine, ketoconazole, miconazole, clotrimazole, DE-11, tamoxifen, quinidine, verapamil can compete for rhodamine 6G's binding site(s) while compounds such as propanil, chloramphenicol, benomyl, voriconazole, tritylimidazole, ketoconazole, miconazole, tamoxifen, gefitinib shared binding site(s) with fluconazole. Nile red mediated efflux appears to be relatively more specific since only five compounds such as ZW3-12, rhodamine 123, miconazole, clotrimazole, and itraconazole can inhibit its accumulation (PubMed:21134356). Does not use as substrates 4-nitroquinoline 1-oxide (4-NQO) and disulfiram (PubMed:21134356). Does not play a role in the azole resistance in mature biofilms (PubMed:18651314).

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