9slq | pdb_00009slq

Trypanosome brucei enolase in complex with a camelid single-domain antibody

spinqualitylabelsall models 9slq, resolution 2.33Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9slq is a 8 chain structure with sequence from Lama glama and Trypanosoma brucei. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.33Å Ligands: CIT, GOL, MG, PEG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q9NDH8_TRYBB Publication Abstract from PubMed Trypanosoma brucei is an extracellular protozoan that causes neglected tropical diseases in both humans and livestock. The parasite has a bipartite life cycle involving an insect vector and a mammalian host. Within the latter, it mainly thrives as a blood-borne parasite that relies on glycolysis to support its energy metabolism. It is for this reason that trypanosomal glycolytic enzymes have been investigated as potential targets for the development of trypanosome-killing drugs. Recent work from our lab has shown that they are also interesting biomarkers for the detection of active trypanosome infections. T. brucei enolase (TbrENO) is a trypanosomal glycolytic enzyme that has gathered interest in both drug and diagnostics development. In this paper, we report the discovery of a camelid single domain antibody (sdAb aka nanobody) that specifically recognises and inhibits TbrENO. The sdAb's inhibitory mechanism is unraveled through a combination of protein biochemistry, biophysics, and structural biology. Structural basis for the inhibition of Trypanosoma brucei enolase by a camelid single-domain antibody.,Li Z, Smiejkowska N, Vansevenant J, Mertens J, Van Wielendaele P, Pinto Torres JE, Magez S, Sterckx YG Mol Biochem Parasitol. 2026 Jul 22;267:111763. doi: , 10.1016/j.molbiopara.2026.111763. PMID:42486369 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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