9sng

CTLH-CRA domain of murine RanBP10 mutant Q519G, F543L, Y548F and V556F

spinqualitylabelsall models 9sng, resolution 1.74Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9sng is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.74Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function RBP10_MOUSE May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (By similarity). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function.

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