9snt

Apo-form of Schistosoma mansoni Cathepsin D1 at 2.2A resolution

spinqualitylabelsall models 9snt, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9snt is a 1 chain structure with sequence from Schistosoma mansoni. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.2Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function G4VEV6_SCHMA Publication Abstract from PubMed Schistosoma mansoni cathepsin D1 (SmCD1) has been shown to be an essential enzyme for helminth metabolism due to its role in haemoglobin degradation: a key amino-acid source for the developing parasite. Therefore, the enzyme is a potential target for the development of antischistosomal inhibitors. SmCD1 has significant sequence identity to cathepsin D-like proteases found in other schistosome species and homology to mammalian aspartic proteases. Here, we report the first crystal structures of a helminth cathepsin D, SmCD1, and have identified a single-domain antibody (nanobody) that specifically binds to SmCD1 with nanomolar affinity but does not recognize human cathepsin D. We have mapped the epitope of the nanobody by determining the crystal structure of the enzyme-nanobody complex, revealing the conformation of SmCD1 in the propeptide-bound state. Crystal structure of Schistosoma mansoni cathepsin D1 in complex with a nanobody reveals the conformation of the propeptide-bound state.,Parker KL, Clarke JD, Liu X, Gomes BF, Eyssen LEA, Furnham N, Paes Silva-Jr F, Owens RJ Acta Crystallogr D Struct Biol. 2026 Feb 1;82(Pt 2):140-150. doi: , 10.1107/S2059798326000422. Epub 2026 Jan 28. PMID:41603320 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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