9srk

Structure of collectin-11 (CL-11) carbohydrate-recognition domain in complex with L-fucose

spinqualitylabelsall models 9srk, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9srk is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.8Å Ligands: CA, FUC, FUL, TRS Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease COL11_HUMAN Craniofacial-ulnar-renal syndrome. The disease is caused by mutations affecting the gene represented in this entry. Function COL11_HUMAN Lectin that binds to various sugars including fucose and mannose. Has a higher affinity for fucose compared to mannose. Does not bind to glucose, N-acetylglucosamine and N-acetylgalactosamine. Also binds lipopolysaccharides (LPS). Involved in fundamental development serving as a guidance cue for neural crest cell migration (By similarity). Publication Abstract from PubMed SARS-CoV-2 respiratory-tract infection affects both vaccinated and unvaccinated persons suggesting factors besides adaptive immunity are operative. We investigated the role of collectin-11 (CL-11), an epithelial-secreted carbohydrate-binding lectin that drives innate immunity and eliminates pathogens by complement activation. SARS-CoV-2, despite binding CL-11 to activate complement, was resistant to lysis. Remarkably, opsonization by CL-11 enhanced virus production by infected respiratory epithelial cells independently of complement. Furthermore, infected cells expressing SARS-CoV-2 spike protein displayed enhanced vulnerability to CL-11 binding and membrane attack by complement. The mechanism of enhanced infectivity was ablated in the presence of L-fucose, which occupied the extended carbohydrate-binding cleft of CL-11 in a crystallographic analysis of complexes between L-fucose and CL-11. Our study suggests pathogenicity of SARS-CoV-2 is related to complement-resistance together with enhanced infectivity and injury of respiratory epithelial cells mediated by locally released CL-11. Glycan recognition by collectin-11 drives SARS-CoV-2 infectivity and membrane injury of respiratory epithelial cells.,Polycarpou A, Wagner-Gamble T, Greenlaw R, O'Neill L, Kanabar V, Alrehaili A, Jeon Y, Baker J, Bafadhel M, Khan H, Malim MH, Romano M, Farrar CA, Smolarek D, Martinez-Nunez R, Doores KJ, Wallis R, Klavinskis LS, Sacks SH Proc Natl Acad Sci U S A. 2025 Oct 28;122(43):e2521209122. doi: , 10.1073/pnas.2521209122. Epub 2025 Oct 24. PMID:41134631 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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