9t64
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Cytoplasmic lattice filament repeat unit with the central FBXW-SKP1 complex
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Structural highlights
FunctionKHDC3_MOUSE Required for maintenance of euploidy during cleavage-stage embryogenesis. Ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process. Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function. Capable of binding RNA.[1] [2] References
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This page was last modified 05:02, 13 August 2026.