| Structural highlights
Function
CTSR1_MOUSE Pore-forming subunit of the CatSper complex, a sperm-specific voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization.[1] [2] [3] [4] [5]
References
- ↑ Ren D, Navarro B, Perez G, Jackson AC, Hsu S, Shi Q, Tilly JL, Clapham DE. A sperm ion channel required for sperm motility and male fertility. Nature. 2001 Oct 11;413(6856):603-9. PMID:11595941 doi:10.1038/35098027
- ↑ Carlson AE, Westenbroek RE, Quill T, Ren D, Clapham DE, Hille B, Garbers DL, Babcock DF. CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14864-8. PMID:14657352 doi:10.1073/pnas.2536658100
- ↑ Carlson AE, Quill TA, Westenbroek RE, Schuh SM, Hille B, Babcock DF. Identical phenotypes of CatSper1 and CatSper2 null sperm. J Biol Chem. 2005 Sep 16;280(37):32238-44. PMID:16036917 doi:10.1074/jbc.M501430200
- ↑ Kirichok Y, Navarro B, Clapham DE. Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel. Nature. 2006 Feb 9;439(7077):737-40. PMID:16467839 doi:10.1038/nature04417
- ↑ Marquez B, Ignotz G, Suarez SS. Contributions of extracellular and intracellular Ca2+ to regulation of sperm motility: Release of intracellular stores can hyperactivate CatSper1 and CatSper2 null sperm. Dev Biol. 2007 Mar 1;303(1):214-21. PMID:17174296 doi:10.1016/j.ydbio.2006.11.007
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