9up5

Crystal structure of LapB from Klebsiella pneumoniae

spinqualitylabelsall models 9up5, resolution 3.44Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9up5 is a 2 chain structure with sequence from Klebsiella pneumoniae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.44Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed LabB (YciM) is a key regulator of lipopolysaccharide (LPS) biosynthesis in Gram-negative bacteria, modulating LpxC degradation to maintain outer membrane integrity. While E. coli LabB (ecLabB) forms a closed-ring dimer via TPR motifs, the crystal structure of Klebsiella pneumoniae LabB (kpLabB) reveals a distinct open-ring dimeric architecture, generated by TPR motif sliding. This alternative conformation suggests a potential mechanism for dynamic regulation and partner interactions. Structural analysis of LabB from Klebsiella pneumoniae reveals an alternative dimeric conformation generated by the sliding of TPR motifs.,Jung KH, Lee SY, Park SE, Kang YW, Park HH Biochem Biophys Res Commun. 2025 Aug 15;775:152151. doi: , 10.1016/j.bbrc.2025.152151. Epub 2025 Jun 3. PMID:40480088 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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