Structural highlights
Function
PG125_VACCW Scaffold protein which forms a transitory spherical honeycomb lattice providing curvature and rigidity to the convex membrane of crescent and immature virions (IV). This association occurs concomitantly with viral membrane formation. Targeted by the drug rifampicin, which prevents the formation of this lattice, and hence virus morphogenesis. In the presence of rifampicin, irregularly shaped membranes that lack the honeycomb layer accumulate around areas of electron-dense viroplasm. This layer is lost from virions during maturation from IV to mature virion (MV), through the proteolysis of OPG158 N-terminus.[1] [2]
References
- ↑ Bisht H, Weisberg AS, Szajner P, Moss B. Assembly and disassembly of the capsid-like external scaffold of immature virions during vaccinia virus morphogenesis. J Virol. 2009 Sep;83(18):9140-50. PMID:19570860 doi:10.1128/JVI.00875-09
- ↑ Hyun J, Matsunami H, Kim TG, Wolf M. Assembly mechanism of the pleomorphic immature poxvirus scaffold. Nat Commun. 2022 Mar 31;13(1):1704. doi: 10.1038/s41467-022-29305-5. PMID:35361762 doi:https://dx.doi.org/10.1038/s41467-022-29305-5
