9ut4

The primase module of the helicase-primase complex from HHV1 bound with ssDNA and amenamevir

spinqualitylabelsall models 9ut4, resolution 2.91Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9ut4 is a 2 chain structure with sequence from Human alphaherpesvirus 1 and Saccharomyces cerevisiae S288C. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.91Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function PRIM_HHV11 Essential component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.[HAMAP-Rule:MF_04011] SUMO_YEAST Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer (PubMed:9312010). Sumoylation, the attachment of SUMO to target proteins, regulates multiple cellular events (By similarity).[UniProtKB:O13351]

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