9uyc

TxtE mutant-H176FA248F With trp

spinqualitylabelsall models 9uyc, resolution 1.53Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9uyc is a 2 chain structure with sequence from Streptomyces scabiei 87.22. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.53Å Ligands: HEM, TRP Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function TXTE_STRSW Cytochrome P450 involved in the biosynthesis of thaxtomins, a family of phytotoxins (PubMed:22941045). Catalyzes direct regiospecific 4-nitration of L-tryptophan, the first committed step in thaxtomin A biosynthesis, using NO and O(2) as cosubstrates (PubMed:22941045, PubMed:25182183). It can use spinach ferredoxin (Fd) and spinach ferredoxin reductase (Fr) as artificial electron donors (PubMed:22941045, PubMed:25182183). Cannot use D-tryptophan (PubMed:22941045). In vitro, it can nitrate unnatural substrates that are structurally similar to L-tryptophan with decorated indole side chains and modified amino acid moieties (PubMed:25182183).

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