9v14

crystal structure of the enzyme-product complex of L-azetidine-2-carboxylate hydrolase

spinqualitylabelsall models 9v14, resolution 0.93Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9v14 is a 1 chain structure with sequence from Pseudomonas sp. A2C. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 0.93Å Ligands: 42B, EDO, FMT, IMD, MG, PEG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A2CH_PSEU6 Catalyzes the hydrolysis of the toxic natural product azetidine-2-carboxylate (an L-proline analog) by opening the azetidine ring to produce 2-hydroxy-4-aminobutanoate. Is thus involved in the detoxification of this compound but also in the degradation pathway of azetidine-2-carboxylate that allows Pseudomonas sp. A2C to grow on azetidine-2-carboxylate as the sole source of nitrogen. Does not show any detectable 2-haloacid dehalogenase activity with either (R)- or (S)-2-chloropropionate as the substrate, and is not able to hydrolyze L-proline.

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