9v2s

Cryo-EM structure of Runella bGSDM pore

spinqualitylabelsall models 9v2s, resolution 3.25Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9v2s is a 92 chain structure with sequence from Runella zeae DSM 19591. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.25Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function GSDM_RUNZN Precursor of a pore-forming protein involved in defense against bacteriophages (By similarity). Cleavage of this precursor by its dedicated, neighboring protease (G563DRAFT_02009) releases the active moiety (gasdermin bGSDM, N-terminus) which inserts into membranes, forming pores and triggering cell death (PubMed:35025633). Expression of bGSDM and its protease is highly toxic in E.coli (PubMed:35025633). Cells expressing the gene pair stop dividing and lose membrane integrity (PubMed:35025633). Both proteins are required to kill E.coli (PubMed:35025633).[UniProtKB:A0A0S2DNG5] Pore-forming protein that causes membrane permeabilization via a pyroptosis-like activity (PubMed:35025633). Makes ring-like pores with walls about 50 Angstroms thick and an interior pore diameter of 200-300 Angstroms, when integrated in liposomes (PubMed:35025633, PubMed:38509367).

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