Structural highlights
Function
INVE_SALTY Involved in the triggering of intracellular events that lead to microbial internalization. These events include increase in calcium level, redistribution of actin microfilaments, and changes in the normal structure of the microvilli. Encoded within the type III secretion system (SPI-1 T3SS), it is essential for the translocation of protein effectors into host cells. Forms a complex with SipB and SipC in the presence of their chaperone SicA. Positively regulates the secretion of SPI-1 T3SS effector proteins SipB, SipC and SipD and negatively influences the secretion of SipA, SopA and SptP.[1] [2]
References
- ↑ Kubori T, Galán JE. Salmonella type III secretion-associated protein InvE controls translocation of effector proteins into host cells. J Bacteriol. 2002 Sep;184(17):4699-708. PMID:12169593 doi:10.1128/JB.184.17.4699-4708.2002
- ↑ Ginocchio C, Pace J, Galán JE. Identification and molecular characterization of a Salmonella typhimurium gene involved in triggering the internalization of salmonellae into cultured epithelial cells. Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5976-80. PMID:1631083 doi:10.1073/pnas.89.13.5976
