9ws4

Cyro-EM structure of the ACT-451840-bound PfMDR1

spinqualitylabelsall models 9ws4, resolution 3.43Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9ws4 is a 1 chain structure with sequence from Plasmodium falciparum 3D7. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.43Å Ligands: A1EYJ Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MDR_PLAF7 Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:35507548, PubMed:37527341). Transports lumefantrine, mefloquine, chloroquine, quinine, quinidine, amodiaquine, piperaquine, dihydroartemisinin and quinacrine (PubMed:35507548).

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