9xs8

Crystal structure of a cupin protein (tm1459, H52A/H54A/H92A/C106E mutant) in ruthenium(p-cymene) bound form

spinqualitylabelsall models 9xs8, resolution 1.26Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9xs8 is a 2 chain structure with sequence from Thermotoga maritima MSB8. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.265Å Ligands: MES, MML, RU Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q9X1H0_THEMA Publication Abstract from PubMed A ruthenium(p-cymene)-cupin complex functioning as an artificial ketone reductase was developed through structure-guided engineering. Refinement of the primary and secondary coordination spheres based on a 1-His metal-binding motif enabled efficient asymmetric transfer hydrogenation of trifluoroacetophenone in water, affording up to 95% ee and 92% coupling efficiency. Rational design of a ruthenium-cupin complex as an artificial ketone reductase.,Matsumoto K, Kitazawa S, Matsumoto R, Morita Y, Fujieda N Chem Commun (Camb). 2026 Mar 17;62(21):5942-5946. doi: 10.1039/d5cc07188g. PMID:41769794 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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