9yd8

Crystal structure of Phospholipase D (PLD) from Arcanobacterium haemolyticum

spinqualitylabelsall models 9yd8, resolution 2.45Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9yd8 is a 2 chain structure with sequence from Actinomycetaceae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.45Å Ligands: GOL, MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function PLD_ARCHD Virulence factor affecting bacterial dissemination and survival within the host. Has magnesium-dependent catalytic activity toward sphingomyelin (SM) and acyl- and alkyl-lysophosphatidylcholine (LPC), but not toward sphingosylphosphorylcholine (SPC) and phosphatidylcholine (PC). Lysophosphatidic acid (LPA), assumed to result from LPC hydrolysis, evokes pathophysiological responses after LPA receptor internalization. Shows hemolytic activity.[UniProtKB:P20626]

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