9ydk

Dickerson dodecamer RNA duplex containing a modified base with a 2-F-6-aminopurine/G mismatch.

spinqualitylabelsall models 9ydk, resolution 1.12Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9ydk is a 1 chain structure with sequence from Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.12Å Ligands: A1CU1, MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed We describe a strategy for the synthesis of DNA, RNA and 2'-O-methyl (2'-O-Me) oligonucleotides containing 2-fluoro-adenine (A(F)) and isoguanine (iG) nucleobases. To the best of our knowledge, this is the first nonenzymatic route for the synthesis of oligonucleotides containing 2-fluoro-adenine. We also describe the hydrolytic strategy for the conversion of 2-fluoro-adenine into isoguanine. Unlike 2,6-diaminopurine, 2-fluoro-adenine and isoguanine modifications are thermally destabilizing in the context of DNA, RNA, and 2'-O-methyl oligonucleotide duplexes. A Postsynthetic Strategy for Oligonucleotides Containing 2-Fluoro-adenine and Isoguanine Nucleobases.,Madaoui M, Kundu J, Datta D, Harp JM, Egli M, Manoharan M Org Lett. 2026 Jul 24;28(29):9133-9138. doi: 10.1021/acs.orglett.6c01203. Epub , 2026 Jul 15. PMID:42455745 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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