Structural highlights
Function
CRT1_OCTBM Chemotactile receptors that mediate contact-dependent chemosensation in cephalopods, allowing them to respond to stimuli in the marine environment (PubMed:33125889, PubMed:37045917, PubMed:37045920, PubMed:40532695). Enriched in the suction cups on the arms, they elicit robust autonomous movement and modify predatory and maternal behavior upon activation (PubMed:37045920, PubMed:40532695). Permeable to cations including sodium, potassium and calcium ions (PubMed:33125889, PubMed:37045920, PubMed:40532695). Binds a wide range of hydrophobic agonists, but the extent of receptor activation is modulated by the electronegativity of the ligands (PubMed:37045920, PubMed:40532695).[1] [2] [3] [4]
References
- ↑ van Giesen L, Kilian PB, Allard CAH, Bellono NW. Molecular Basis of Chemotactile Sensation in Octopus. Cell. 2020 Oct 29;183(3):594-604.e14. PMID:33125889 doi:10.1016/j.cell.2020.09.008
- ↑ Kang G, Allard CAH, Valencia-Montoya WA, van Giesen L, Kim JJ, Kilian PB, Bai X, Bellono NW, Hibbs RE. Sensory specializations drive octopus and squid behaviour. Nature. 2023 Apr;616(7956):378-383. PMID:37045917 doi:10.1038/s41586-023-05808-z
- ↑ Allard CAH, Kang G, Kim JJ, Valencia-Montoya WA, Hibbs RE, Bellono NW. Structural basis of sensory receptor evolution in octopus. Nature. 2023 Apr;616(7956):373-377. PMID:37045920 doi:10.1038/s41586-023-05822-1
- ↑ Sepela RJ, Jiang H, Shin YH, Hautala TL, Clardy J, Hibbs RE, Bellono NW. Environmental microbiomes drive chemotactile sensation in octopus. Cell. 2025 Sep 4;188(18):4849-4860.e21. PMID:40532695 doi:10.1016/j.cell.2025.05.033
