9yl3

State 1 MLL4FC bound to a nucleosome premodified with H2BK120ub and H4K16ac

spinqualitylabelsall models 9yl3, resolution 3.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9yl3 is a 15 chain structure with sequence from Homo sapiens and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.5Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease KMT2D_HUMAN Kabuki syndrome. The disease is caused by mutations affecting the gene represented in this entry. Function KMT2D_HUMAN Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. A0A6P6IDI8_PUMCO

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