9z3q

Cryo-EM structure of KSHV glycoprotein gHgL in complex with MLKH3 and MLKH10 FABs

spinqualitylabelsall models 9z3q, resolution 3.51Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9z3q is a 6 chain structure with sequence from Human gammaherpesvirus 8 and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.51Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function GH_HHV8P The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis (By similarity). Targets host EPHA2 to promote KSHV entry.[HAMAP-Rule:MF_04033]

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