9z4h

Cryo-EM structure of human Wntless in complex with Wnt5a at 1:1 stoichiometry

spinqualitylabelsall models 9z4h, resolution 2.64Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9z4h is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.64Å Ligands: CLR, LPE, NAG, PAM, PCW Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease WNT5A_HUMAN Autosomal dominant Robinow syndrome. The disease is caused by variants affecting the gene represented in this entry. Function WNT5A_HUMAN Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor (PubMed:15735754). Mediates motility of melanoma cells (PubMed:17426020). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity).[UniProtKB:P22725][UniProtKB:Q27Q52]

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