9zdq | pdb_00009zdq

Cryo-EM structure of ARAF-MEK1 complex with GDC-0879 and a covalent MEK inhibitor TWG-07-148

spinqualitylabelsall models 9zdq, resolution 2.51Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9zdq is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.51Å Ligands: 29L, A1C1Y, ANP Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function ARAF_HUMAN Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.

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