9zhh

Cryo-EM structure of IGFBP7 dodecamer. The 3D refinement was focused on the central part of the dodecamer, which contains 12 IgC2 domains.

spinqualitylabelsall models 9zhh, resolution 3.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9zhh is a 12 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.4Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease IBP7_HUMAN Familial retinal arterial macroaneurysm. The disease is caused by variants affecting the gene represented in this entry. Function IBP7_HUMAN Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.

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