Acetyl-CoA carboxylase

spinqualitylabelsall models E. coli Acetyl-CoA carboxylase biotinyl domain complex with biotin (PDB code 1bdo) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Acetyl-CoA carboxylase (ACC) catalyzes the irreversible carboxylation of acetyl-CoA to malonyl-CoA. Malonyl-CoA is a building block in in the biosynthesis of fatty acids. ACC is biotin- and ATP-dependent enzyme. In mammals, 2 forms of ACC exist. ACC1 and ACC2 differ in their tissue distribution and function. See also 3-Hydroxypropionate bicycle. Structural highlights ACC is a multi-subunit enzyme in prokaryotes and plants. Each subunit catalyzes different reaction. These are – biotin carboxylase (BC) which carboxylates the biotin prosthetic group, biotin carboxyl carrier protein (BCCP) which is linked covalently to biotin and carboxyltransferase (CT) which transfers the carboxyl group from biotin to acetyl-CoA. In eukaryotes these functions are performed by a single polypeptide chain. The biotin moiety is located in the beta turn connecting the N and C halves of BCCP. E.coli biotin carboxylase complex with biotin (1bdo) is shown. Water molecules shown as red spheres. Disease Bacterial ACC serves as a potential drug target for novel antibiotics. 3D structures of acetyl-CoA carboxylase Acetyl-CoA carboxylase 3D structures

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