3-Hydroxypropionate bicycle

spinqualitylabelsall models E. coli Acetyl-CoA carboxylase biotinyl domain complex with biotin (PDB code 1bdo) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D The 3-Hydroxypropionate bicycle, also known as the 3-Hydroxypropionate pathway, is a process that allows some bacteria to generate 3-Hydroxypropionate utilizing carbon dioxide. In this pathway CO2 is fixed (i.e. incorporated) by the action of two enzymes, acetyl-CoA carboxylase and propionyl-CoA carboxylase. See also Carbon Fixation. These enzymes generate malonyl-CoA and (S)-methylmalonyl-CoA, respectively. Malonyl-CoA, in a series of reactions is further split into acetyl-CoA and glyoxylate. Glyoxylate is incorporated into beta-methylmalyl-CoA which is then split, again through a series of reactions to release pyruvate as well as acetate, which is used to replenish the cycle.

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