Alanine racemase

spinqualitylabelsall models Structure of alanine racemase dimer complex with phosphopyridoxyl-alanine (in magenta) (PDB entry 1l6g) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Alanine racemase (AR) catalyzes the racemization of L-alanine to D-alanine. AR uses pyridoxal-5’-phosphate (PLP) as a cofactor. PLP binds to a lysine residue of AR. AR participates in alanine and aspartate metabolism. Disease The antibiotic D-cycloserine is an effective inhibitor of AR. Relevance The D-alanine produced by AR is used for peptidoglycan biosynthesis. Peptidoglycans are found in cell walls of bacteria hence AR inhibitors are tested as antimicrobial drugs. Structural highlights AR uses 2 catalytic bases for the reaction: Lys and Tyr from different monomers. Water molecules are shown as red spheres. Whole active site. 3D Structures of alanine racemase Alanine racemase 3D structures

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