Aquaporin

spinqualitylabelsall models Human aquaporin 1, 1h6i Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Aquaporins are channel producing proteins which regulate the flow of water across the cell membrane. Aquaporin-0 functions as water channel in lens fibers. Aquaporin-1 see details in Aquaporin-1. Aquaporin-2 function is to reabsorb water from urine in the kidney. Aquaporin-3 function is to promote glycerol permeability across cell membrane. Aquaporin-4 regulates water balance in the central nervous system. Aquaporin-5 is implicated in the forming of saliva, tears and pulmonary secretions. Aquaporin-7 regulates nutrient availability and signaling responding to cellular stress Aquaporin-10 is expressed exclusively in adipocytes and participates in maintaining low glycerol content in them NIP-2 aquaporin Nodulin 26-like intrinsic protein is a plant Aquaporin TIP-2 aquaporin is permeable to water and ammonia Aquaporin-Z is a major water channel in bacteria. Aquaglycerolporin (GLpf) is a water channel which can transport glycerol, polyalcohols, urea and other small solutes. Disease Mutations in aquaporin-2 cause diabitis insipidus. Mutations in aquaporin-0 in mice cause congenital cataracts. Aquaporin-4 is the primary autoimmune target of neuromyelitis optica. Structural highlights Aquaporins are made of α-helix bundles. The water transporting channel contains 2 restriction sites conferring an hourglass model to the channel. Two NPA motifs from opposite surfaces form one restriction. Another restriction is formed by a cluster of aromatic/arginine side chains which serves to weaken the hydrogen bonding between water molecules. 3D Structures of Aquaporin Aquaporin 3D structures

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