Function
Arginase (Arg) catalyzes the conversion of arginine to ornithine and urea. Arg is the final enzyme in the urea cycle. Arg requires 2 manganese ions for functioning.[1]
Disease
Arg deficiency is an inherited disorder causing the accumulation of toxic urea in the blood.
Structural highlights
The manganese ions are located at the bottom of a 15A cleft. Active site. The proposed reaction mechanism involves H141, D128, E277 in rat.[2]
3D structures of arginase
Arginase 3D structures
- ↑ Dowling DP, Di Costanzo L, Gennadios HA, Christianson DW. Evolution of the arginase fold and functional diversity. Cell Mol Life Sci. 2008 Jul;65(13):2039-55. doi: 10.1007/s00018-008-7554-z. PMID:18360740 doi:https://dx.doi.org/10.1007/s00018-008-7554-z
- ↑ Cox JD, Cama E, Colleluori DM, Pethe S, Boucher JL, Mansuy D, Ash DE, Christianson DW. Mechanistic and metabolic inferences from the binding of substrate analogues and products to arginase. Biochemistry. 2001 Mar 6;40(9):2689-701. PMID:11258880
