Beta-lactamase

spinqualitylabelsall models Class Bβ-lactamase Ndm-1 complex with Zn+2 (grey) (PDB code 3spu) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Beta-lactamase (Blac) are enzymes which make bacteria resistant to β-lactam antibiotics by breaking their β-lactam ring. Blac are classified according to their resistance targets. Class A are broad-spectrum. See also TEM1 Class Antibiotic Resistance Proteins. Class B are metalloenzymes. See also New Delhi metallo-β-lactamase 1. Class C are cephalosporinases. See also Class C beta-lactamase. Class D are cloxacilanases Carbapenemase (Car) are Blac with wide hydrolytic capacities. Car can hydrolyze penicillins, cephalosporins, monobactams and carbapenems. Extended-spectrum Blac class A (ESBL) hydrolyze penicillins but not cephalosporins. Serine beta-lactamase (ClbP) has a serine-active site. AmpC beta-lactamase (ClbP) mediate resistance to cephalosphin, cefazolin,cefoxitin and most penicillins. Relevance Blac makes some bacteria resistant to antibiotics like penicillin, cephamycin and carbapenems. Structural highlights The active site of class B Blac contains 2 Zn+2 ions. See also Journal:Structure:1 3D Structures of Beta-lactamase Beta-lactamase 3D structures

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