Bungarotoxins. α-Bungarotoxin (α-BGT), β-Bungarotoxin (β-BGT), γ-Bungarotoxin (γ-BGT) and κ-Bungarotoxin (κ-BGT) are snake toxins from banded krait.
- α-BGT binds irreversibly to the acetylcholine receptor (AChR) causing paralysis and death. See details in Alpha-bungarotoxin.
- β-BGT binds to the presynaptic terminal causing release of acetylcholine.
- γ-BGT inhibits the binding of quinoclidinyl bezilate to the M2 muscarinic acetylcholine receptor.
- κ-BGT binds weakly to the nicotinic acetylcholine receptor.
For toxins in Proteopedia see Toxins.
Iod coordination site in α-Bungarotoxin (PDB code 1hc9).[1] Water molecule shown as red sphere.
3D Structures of Bungarotoxin
Bungarotoxin 3D structures
- ↑ Harel M, Kasher R, Nicolas A, Guss JM, Balass M, Fridkin M, Smit AB, Brejc K, Sixma TK, Katchalski-Katzir E, Sussman JL, Fuchs S. The binding site of acetylcholine receptor as visualized in the X-Ray structure of a complex between alpha-bungarotoxin and a mimotope peptide. Neuron. 2001 Oct 25;32(2):265-75. PMID:11683996
