CD4

spinqualitylabelsall models Structure of CD4 (green) complex with antibody light chain (pink), heavy chain (yellow), HIV-1 gp120 (cyan), TRIS and hexane-diol (PDB entry 2nxy) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function CD4 (or Cluster of Differentiation 4 or T cell surface glycoprotein CD4) is a glycoprotein found on the surface of immune cells. CD4 has 4 immunoglobulin (Ig) domains (D1-D4), a transmembrane domain and a cytoplasmic tail domain. D1 and D3 resemble Ig variable domain and D2 and D4 resemble the Ig constant domain. The D1 domain interacts with class II MHC molecules. CD4 helps T-cell receptors (TCR) interact with antigen-presenting cells. The CD4 tail interacts with tyrosine kinase Lck which activates molecular components of the signaling pathway. Relevance HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell. CD4 with antibody and HIV-1 gp120 (2nxy). 3D structures of CD4 CD4 3D structures

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Michal Harel, Alexander Berchansky