CXC chemokine receptor type 4

spinqualitylabelsall models Human CXCR4/lysozyme chimera complex with cyclic peptide antagonist CVX15 (PDB code 3oe0) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D CXC chemokine receptors bind to cytokines of the CXC chemokine family. CXCR4 is specific for Stromal Derived Factor 1 (SDF-1α, known also as CXCL12). The CXCR4 is used by HIV to infect CD4+ T cells. The biological unit probably is a dimer . CXCR1 recognizes CXC chemokines with ELR amino acids adjacent to the C-terminal CXC motif. Ligand binding cavity with antagonist citrulline (PDB code 3oe0). Ligand binding cavity with antagonist citrulline, receptor is in spacefill representation. Ligand binding cavity with antagonist citrulline, receptor surface is shown. See also: Receptor Transmembrane (cell surface) receptors G protein-coupled receptors

3D Structures of CXC chemokine receptor type 4

Updated on 13-September-2021

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• CXC chemokine receptor type 4
  • Stromal Derived Factor 1 – hCXCR4 residues 2-229 (mutant)/lysozyme residues 1002-1161+antagonist – human
    
  • 3oe0, Receptor, Transmembrane (cell surface) receptors, G protein-coupled receptors, 4rws – hCXCR4 residues 2-229 (mutant)/lysozyme residues 1002-1161/hCXCR4 residues 231-319+antagonist
    
  • 2k03, 2k04, 2k05 - hCXCR4 N-terminal (mutant)+hSDF-1 (mutant) - NMR
    
  • 2n55– hCXCR4 N-terminal + stromal cell-derived factor 1
    

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