Calcium/calmodulin-dependent protein kinase kinase

spinqualitylabelsall models Human CaMKKβ complex with the thiadiazinone inhibitor and Mg+2 ion (green) (PDB code 5vt1) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Calcium/calmodulin-dependent protein kinase kinase (CaMKK) is the kinase responsible for the α-lipoic acid-induced AMP-activated protein kinase (AMPK) activation in myotubes. CaMKK phosphorylates and activates CaMKI. CaMKK is inhibited by phosphorylation by cAMP-dependent protein kinase. There are 2 genes of CaMKK termed α and β. CaMKKβ can activate AMPK while CaMKKα can not. Relevance CaMKK β is neuroprotective in stroke in aged mice hence it may be a potential target for reducing long-term disability after stroke. Structural highlights The thiadiazinone inhibitor of CaMKKβ displays two direct contact points to the hinge region of CaMKKβ ATP-binding pocket. All inhibitor interactions. Water molecules are shown as red spheres.

3D structures of calcium/calmodulin-dependent protein kinase kinase

Updated on 25-December-2024

6ccf, 6cd6 - hCaMKKαA + inhibitor - human
5uy6, 5uyj - hCaMKKβB
5vt1, 6bku, 6ble, 6bql, 6bqq, 6brc, 6cmj, 2zv2 - hCaMKKβB + inhibitor
5yv8, 5yv9, 5yva, 5yvb, 5yvc, 8tuc - hCaMKKβ + inhibitor
6bqp - hCaMKKβB + drug
6fel - hCaMKKβ + 14-3-3 protein g
1ckk - CaMKK1 calmodulin-binding domain + calmodulin - rat - NMR

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