Catabolite gene activator protein

spinqualitylabelsall models Catabolite gene activator protein complex with cAMP and DNA (1o3r) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Catabolite gene activator protein (CAP) is a DNA-binding protein involved in the transcription of several genes including those involved in the metabolism of sugar. CAP can activate or repress transcription initiation upon binding of cAMP. The cAMP-CAP complex binds to promoters on the DNA. The structure contains a ligand-binding domain (LBD) at the N-terminal and DNA-binding domain (DBD) at the C-terminal. Four cAMP molecules bind to the dimeric CAP. When the amount of glucose transported into the cell is low, cAMP level rises and the cAMP-CAP complex causes increase of transcription of glucose metabolism genes. See also CAMP-dependent pathway and CAMP is second messenger. 1st cAMP binding site 2nd cAMP binding site in E. coli Catabolite gene activator protein (1o3r). Water molecules are shown as red spheres. 3D Structures of catabolite gene activator protein Catabolite gene activator protein 3D structures

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