Cephalosporin acylase

spinqualitylabelsall models Cephalosporin acylaseα subunit (magenta) and β subunit (green) complex with glutarate (PDB entry 1jw0) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Cephalosporin acylase (CSA) catalyzes the conversion of cephalosporin C (CPC) to 7-amino-cephalosporanic acid (7-ACA). Relevance CSA is used commercially for production of semi-synthetic cephalosporin antibiotics. Structural highlights CSA contains 2 non-identical subunits. The active site pocket (PDB entry 1jw0) of CSA is similar to that of penicillin acylase. Water molecules are shoen as red spheres. CSA precursor is cleaved at 2 sites forming the active heterodimer. 3D structures of cephalosporin acylase Cephalosporin acylase 3D structures

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