Cullin 3D structures

3D Structures of cullin

Updated on 11-February-2025

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• Cullin-1
  • 1ldj – hCul1 + RBX1 – human
    
  • 3rtr – hCul1 residues 411-766 (mutant) + RBX1
    
  • 5v89 – hCul1 WHB domain residues 702-776 + Dcn1-like protein
    
  • 3tdu – hCul1 WHB domain + Dcn1-like protein + NEDD8-conjugating enzyme Ubc12
    
  • 3tdz – hCul1 WHB domain + Dcn1-like protein + stapled Ubc12 peptide
    
  • 8caf – hCul1 + antibody + NEDD8
    
  • 1ldk – hCul1 + RBX1 + cyclin A/Cdk2-asociated protein + Skp2-like protein
    
  • 1u6g – hCul1 + RBX1 + TIP120 protein
    
  • 7b5s – hCul1 + RBX1 + ARIH1 – Cryo EM
    
  • 7b5n – hCul1 + RBX1 + ARIH1 + NEDD8 + Ub + UBE2L3 – Cryo EM
    
  • 7b5m – hCul1 + RBX1 + ARIH1 + SKP1 + SKP2 + CKSHS1 + p27 + Ub – Cryo EM
    
  • 7b5r – hCul1 + RBX1 + cyclin A + SKP1 + SKP2 + CKSHS1 + p27 + CDK2 – Cryo EM
    
  • 7b5l – hCul1 + RBX1 + cyclin A + SKP1 + SKP2 + CKSHS1 + p27 + CDK2 + NEDD8 + cyclin A + Ub + UBE2L3 – Cryo EM
    
  • 4f52 – hCul1 residues 411-690 (mutant) + RBX1 + glomulin
    
  • 4p5o – hCul1 residues 411-776 + DCNL1 + NEDD8-conjugating enzyme Ubc12 + RBX1 + NEDD8-conjugating enzyme Ubc12 + NEDD8
    
  • 6ttu – hCul1 + RBX1 + NEDD8 + polyubiquitin + Ube2D2 + SKP + F-box/WD repeat-containing protein + IKBA peptide – Cryo EM
    
  • 8vvy – hCul1 + CAND2 – Cryo EM
    
  • 7z8r – hCul1 + RBX1 + CAND2 – Cryo EM
    
  • 7zbz – hCul1 + RBX1 + CAND2 + SKP1 + SKP2 – Cryo EM
    
  • 7z8t, 7z8v, 7zbw, 8cdj, 8cdk – hCul1 + RBX1 + CAND1 + SKP1 + SKP2 – Cryo EM
    
  • 8ubt, 8ubu – hCul1 + Fbox17 + BACH1+ SKP1 – Cryo EM
    
  • 8ua6 – hCul1 + Fbox22 + BACH1+ SKP – Cryo EM
    
  • 8or3 – hCul1 + RBX1 + CAND1 + SKP1 + DCNL1 – Cryo EM
    
  • 8or0, 8or4 – hCul1 + RBX1 + CAND1 + SKP1 + SKP2 + CKS-1 + cyclin-dependent kinase 2 – Cryo EM
    
  • 8or2 – hCul1 + RBX1 + CAND1 + DCNL1 – Cryo EM
    
  • 6wcq – hCul1 + SKP + F-box/WD repeat-containing protein + Kelch-like ECH-associated protein – Cryo EM
    
  • 9jkb – hCul1 in SCF ubiquitin ligase complex – Cryo EM
    
• Cullin-2
  • 4wqo – hCul2 residues 20-122 + PVHL + elongin-C
    
  • 5n4w – hCul2 + PVHL + elongin-B + elongon-C + RBX1 +
    
  • 8ij1, 8je1 – hCul2 + elongin-B + elongin-C + RBX1 + FEM1B – Cryo EM
    
  • 8wqa, 8wqb, 8wqh – hCul2 + elongin-B + elongin-C + RBX1 + FEM1B + BC8 orange-interacting protein – Cryo EM
    
  • 8wqc – hCul2 + elongin-B + elongin-C + RBX1 + FEM1B + NEDD8 – Cryo EM
    
  • 8wqe, 8wqf, 8wqg – hCul2 + elongin-B + elongin-C + RBX1 + FEM1B + degron – Cryo EM
    
  • 8je2 – hCul2 + elongin-B + elongin-C + RBX1 + FEM1B + FNIP1 – Cryo EM
    
  • 8pql – hCul2 + elongin-B + elongin-C + RBX1 + FEM1C + ubiquitin + polyubiquitin + ubiquitin-conjugating enzyme E2 – Cryo EM
    
  • 8q7r – hCul2 + elongin-B + elongin-C + RBX1 + FEM1C + ubiquitin + SIL1 + ubiquitin-conjugating enzyme E2 – Cryo EM
    
  • 8jal, 8jaq, 8jar, 8jas, 8jav – hCul2 + elongin-B + elongin-C + RBX1 + amyloid protein-binding protein + degron – Cryo EM
    
  • 8rwz – hCul2 + elongin-B + elongin-C + RBX1 + PVHL + HUNK1 – Cryo EM
    
  • 8r5h – hCul2 + elongin-B + elongin-C + RBX1 + ubiquitin + ubiquitin-conjugating enzyme E2 + PVHL + HUNK1 – Cryo EM
    
  • 8rx0 – hCul2 + elongin-B + elongin-C + RBX1 + polyubiquitin + ubiquitin-conjugating enzyme E2 + PVHL + HUNK1 + NEDD8 – Cryo EM
    
  • 8qu8 – hCul2 + elongin-B + elongin-C + RBX1 + PVHL + Kras – Cryo EM
    
  • 8wdk – hCul2 + elongin-B + elongin-C + RBX1 + PVHL + Wee1-like protein kinase – Cryo EM
    
  • 6r6h, 6r7f, 6r7h, 6r7i, 6r7n – hCul2 in signalosome COP9 – Cryo EM
    
  • 7plo – hCul2 in replisome complex – Cryo EM
    
• Cullin-3
  • 8k8t – hCul3 + kelch-like protein – Cryo EM
    
  • 8k9i, 8khp – hCul3 + RBX1 + kelch-like protein – Cryo EM
    
  • 8i79 – hCul3 (mutant) + KCTD7 – Cryo EM
    
  • 5nlb – hCul3 N terminal + kelch-like protein
    
  • 6i2m – hCul3 (mutant) + kelch-repeat protein
    
  • 8gq6, 8h33, 8h34, 8h35, 8h36, 8h3r – hCul3 + RBX1 + kelch-repeat protein – Cryo EM
    
  • 8h3q – hCul3 + RBX1 + CAND1 – Cryo EM
    
  • 8h37 – hCul3 + RBX1 + kelch-repeat protein + p85A – Cryo EM
    
  • 4ap2, 4apf, 4hxi – hCul3 N terminal (mutant) + kelch-like protein
    
  • 4eoz – hCul3 N terminal (mutant) + peckle-type POZ protein
    
  • 2myl, 2mym – hCul3 residues 49-68 - NMR
    
  • 8u80, 8u81, 8u82, 8u83, 8u84 – hCul3 + KCTD5 + Gbeta1gamma2 complex – Cryo EM
    
  • 8h38, 8h3a, 8h3f – hCul3 in signalosome COP9 – Cryo EM
    
• Cullin-4A
  • 2hye – hCul4A + RBX1 + DDB1 + nonstructural protein
    
  • 4a0k – hCul4A + RBX1 + DDB1 + DDB2 + DNA
    
  • 7okq – hCul4A + RBX1 + DDB1 + DCAF1 – Cryo EM
    
  • 8b3i – hCul4A + RBX1 + DDB1 + NEDD8 + CSA + E2 + Ub – Cryo EM
    
  • 7opc, 7opd – hCul4A in transcription- DNA repair complex – Cryo EM
    
• Cullin-4B
  • 8ei1 – hCul4B N terminal + H316 peptide
    
  • 4a64 – hCul4B residues 188-539
    
  • 2do7 – hCul4B winged helix-turn-helix - NMR
    
  • 4a0c – hCul4B residues 192-913 + RBX1 + cullin-associated NEDD8-dissociated protein
    
  • 4a0l – hCul4B + RBX1 + DNA damage-binding protein 1 + DNA damage-binding protein 2 + DNA
    
• Cullin-5
  • 2wzk – hCul5 N terminal 1-386 (mutant)
    
  • 8ei2 – hCul5 N terminal + H314 peptide
    
  • 3dpl – hCul5 C-terminal residues 401-780 (mutant) + RBX1
    
  • 3dqv – hCul5 C-terminal (mutant) + RBX1 + NEDD8
    
  • 6v9i – hCul5 + RBX2 – Cryo EM
    
  • 7oni – hCul5 + RBX2 + NEDD8 + ARIH2 – Cryo EM
    
  • 4jgh – hCul5 N terminal (mutant) + SOCS-2 + transcription elongation factor B
    
  • 4n9f – hCul5 N terminal + core-binding factor + virion infectivity factor + transcription elongation factor B
    
  • 8fvj – hCul5 + elongin-B + elongin-C + CBF-beta + VIF – Cryo EM
    
  • 8fvi – hCul5 + elongin-B + elongin-C + CBF-beta + VIF + APOBEC3H + RNA – Cryo EM
    
• Cullin-7
  • 2jng – hCul7 residues 360-460 - NMR
    
  • 7z8b – hCul7 + RBX1 + F-box/WD repeat-containing protein 8 + S-phase kinase-associated protein – Cryo EM
    
• Cullin-9
  • 8q7e, 8rhz – hCul9 + RBX1 – Cryo EM
    
  • 8q7h – hCul9 + RBX1 + NEDD8 – Cryo EM
    
• Cullin-A
  • 3o2p, 3o6b – CulA residues 730-815 + defective in cullin neddylation protein - yeast

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel