Cystathionine gamma synthase

spinqualitylabelsall models Tobacco cystathionine gamma synthatase complex with inhibitor (PDB code 1i41) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Cystathionine gamma synthase (CGS) catalyzes the formation of cystathionine and succinate from cysteine and succinyl homoserine in microorganisms and plants. This reaction is part of Met biosynthesis pathway. Relevance CGS deletion mutants in bacteria caused lack of growth which was reversed by addition of Met. CGS is a target of antimicrobial agent and herbicides. Structural highlights The 3D structure of tobacco CGS complex with an inhibitor shows the interaction of the inhibitor in the substrate binding pocket of CGS dimer. The carboxylate moiety of the inhibitor makes hydrogen bond to Arg and its phosphonate group binds to phosphate recognition group formed by residues from both monomers.

3D structures of cystathionine gamma synthase

Updated on 20-February-2025

1i41 - tCGS + inhibitor - tobacco
1qgn - tCGS + PLP
1i43, 1i48 - tCGS + PLP + inhibitor
1cs1 - CGS + PLP derivative - Eschericia coli
4l0o - CGS + PLP - Helicobacter pylori
6s0c - CGS + PLP - Citrobacter freundii
9axj - CGS + Pyridine derivative – Thermobifida fusca
3qi6, 3qhx - CGS MetB - Mycobacterium ulcerans
5x5h - CGS MetB - Corynebacterium glutamicum
6ld7 - XoCGS (mutant`) + PLP derivative - Xanthomonas oryzae
6ld9 - XoCGS (mutant`) + cystathionine
6ld8 - XoCGS (mutant`) + cysteine + aminoacrylate
6lgo - XoCGS (mutant`) + homolanthionine

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