Cytolysin

spinqualitylabelsall models Cytolysin complex with N-acetyl-D-galactosamine and glycerol (PDB code 4owk). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Cytolysins are β-barrel (Alpha Helices, Beta Strands , Loops , Turns) pore-forming toxins secreted by a variety of organisms and causing cell lysis. Anthrolysin O is a pore-forming, cholesterol-dependent cytolysin secreted by Bacillus anthracis. Equinatoxin is an α-helical pore-forming toxin that pirate cellular membranes by the use of α-helices . Fragaceaatoxin is a sea anemone toxin . Intermedilysin is human-specific toxin found in liver abscesses . Listerolysin O is a pore-forming, cholesterol-dependent cytolysis secreted by Listeria monocytogenes. Lysenin is small β-pore-forming toxin secreted by an earthworm. Perforin is produced by killer lymphocytes and released by cytoplasmic granules. Perfringolysin O is a pore-forming, cholesterol-dependent cytolysin secreted by Clostridium perfringens. Pneumolysin is a virulence factor which augments intrapulmonary growth and dissemination during the early infection Streptococcus pneumonia. Sticholysin is a pore-forming toxin secreted by sea anemone. Stonustoxin is a lethal factor secreted by stonefish. Streptolysin O is a thin-activated membrane-damaging protein which is produced by β-hemolytic group A streptococci. See also Cytolysin A and Hemolysin. Relevance Steptolysin O has the potential to establish a new class of suicide gene therapeutic reagents as well as reversibly permeabilize adherent and non-adherent cells allowing the delivery of molecules with up to 100 kDa mass to the cytosol. Structural highlights Cytolysin β-trefoil lectin binds a disaccharide. 3D structures of Cytolysin Cytolysin 3D structures

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