DXP reductoisomerase

spinqualitylabelsall models DXP reductoisomerase complex with NADPH, Mn+2 ion (green) and anti-malaria drug fosmidomycin (PDB code 3zhy) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function DXP reductoisomerase (DXR) or 1-deoxy-D-xylulose-5-phosphate reductoisomerase or IspC catalyzes the conversion of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate. DXR is part of the nonmevalonate pathway which synthesizes isoprenoids which are essential components of bacterial cell wall. NADPH is a cofactor of the reaction. Divalent metal cations (Mg+2, Mn+2) are involved in binding of the DXP substrate to DXR. Disease The antibiotic fosmidomycin is a structural analog of 2-C-methyl-D-erythritol 4-phosphate is a powerful inhibitor of DXR and is used as an anti-malaria drug. Structural highlights DXR active site contains Mn+2 cation and the product analog fosmidomycin. Click here to see NADPH binding site (water molecules shown as red spheres). 3D Structures of DXP reductoisomerase DXP reductoisomerase 3D Structures

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