Dihydroorotate dehydrogenase

spinqualitylabelsall models Human dihydroorotate dehydrogenase with FMN complex with orotate and inhibitor brequinar (PDB entry 2b0m) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Dihydroorotate dehydrogenase (DHOD) catalyzes the conversion of dihydroorotate to orotate. DHOD (quinone) (DHODH) or DHOD mitochondrial catalyzes the conversion of dihydroorotate and quinone to orotate and quinol. DHOD (fumarate) (DHODF) catalyzes the conversion of dihydroorotate and fumarate to orotate and succinate. DHOD is part of the biosynthesis of pyrimidine. FMN is the cofactor in this reaction. Relevance Leflunomide and brequinar are anti-rheumatic drugs which bind to DHOD. Structural highlights DHOD FMN/orotate binding site. The inhibitor brequinar binds DHOD in the quinone binding channel. See also this representation of brequinar binding. 3D Structures of dihydroorotate dehydrogenase Dihydroorotate dehydrogenase 3D structures

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