Engulfment and cell motility protein 1

spinqualitylabelsall models Human SeMet ELMO1 C-terminal PH domain (green) complex with DOCK2 SH3 domain (cyan) (PDB code 3a98) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Engulfment and cell motility protein 1 (ELMO1) or CED-12 homolog mediates tumour progression by increasing cell motility and inhibiting apoptosis in human colorectal cancer. Complex formation of ELMO1 with dedicator of cytokinesis 2 (DOCK2) is necessary for DOCK2-mediated Rac signaling. Disease Studies have shown that ELMO1 polymorphism is associated with diabetic nephropathy. Structural highlights The complex of ELMO1 and DOCK2 is formed between the C-terminal of ELMO1 and the SH3 domain of DOCK2. The Pro-rich C-terminal of ELMO1 which includes the binding PxxP motif, forms a five helix bundle with the DOCK2 SH3 domain. 3D structures of engulfment and cell motility protein 1 Updated on 26-May-2025 6jpp – hELMO1 RBD domain 1-113 – human - NMR 7y4a – hELMO1 RBD domain + RhoG 2vsz – hELMO1 PH domain 532-727 6tgb – hELMO1 + DOCK2 – Cryo EM 8jhk – hELMO1 + DOCK5 – Cryo EM 3a98 – hELMO1 PH domain + DOCK2 6tgc – hELMO1 + DOCK2 + Rac1 – Cryo EM 7dpa, 8zji, 8zjj, 8zjk, 8zjl, 8zjm – hELMO1 + DOCK5 + Rac1 – Cryo EM 8xm7, 8zj2 – hELMO1 + DOCK5 + Rac1 + RhoG – Cryo EM 6uka – mELMO1 RBD domain + RhoG - mouse

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