Epithelial discoidin domain-containing receptor

spinqualitylabelsall models Human DDR1 kinase domain complex with imatinib and ethylene glycol (PDB code 4bkj) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Epithelial discoidin domain-containing receptor (DDR1 and DDR2) are extracellular matrix-sensing Receptor tyrosine kinases which are activated by collagen and are expressed in bronchial epithelium. They are responsible for maintaining the normal structure of skin and kidney epithelia. DDR1 and DDR2 function as sensors for extracellular matrix and to regulate a wide range of cell functions from migration and proliferation to cytokine secretion and extracellular matrix homeostasis/remodeling. See also Kinase-linked, enzyme-linked and related receptors. Disease DDR1 promotes inflammation in atherosclerosis, lung fibrosis and kidney injury Relevance DDR1 plays a consequential role in a variety of cancers. A low DDR1/high DDR2 profile is associated with high tumor grade and may identify invasive carcinomas with worse prognosis. Structural highlights DDR1 contains a discoidin domain. This domain is about 150 amino acid long and is found in many blood coagulation factors. The structure of the complex between DDR1 and imatinib shows hydrogen bonds interactions between the anti-cancer drug and the kinase domain including bonds with the kinase allosteric site Asp-Phe-Gly (DFG motif). Water molecules are shown as red spheres.

3D structures of epithelial discoidin domain-containing receptor

Updated on 01-June-2025

{"openlevels":0}

• Epithelial discoidin domain-containing receptor 1; Domains – discoidin 26-186; ligand-binding 283-385; kinase 543-913
  • Receptor tyrosine kinases, Kinase-linked, enzyme-linked and related receptors – hDDR1 kinase domain – human
    
  • 3zos, 4bkj, 6bsd – hDDR1 kinase domain + cancer drug
    
  • 6few – hDDR1 kinase domain + alport syndrome drug
    
  • 6fex, 6fil,6fin, 6fio, 6fiq – hDDR1 kinase domain (mutant) + alport syndrome drug
    
  • 4ckr, 5bvn, 5bvo, 5bvw, 5fdp, 5fdx, 5sau, 5saw, 5sax, 5say, 5saz, 5sb0, 5sb1, 5sb2, 6brj, 6gwr, 6hp9, 7bcm, 7be6, 7feh – hDDR1 kinase domain + inhibitor
    
  • 4ag4 – hDDR1 29-367 domain + antibody
    
  • 8pe9 – hDDR1 188-370 domain + antibody
    
• Epithelial discoidin domain-containing receptor 2
  • 2z4f – hDDR2 discoidin domain – NMR
    
  • 2wuh – hDDR2 discoidin domain + collagen
    
  • 6fer, 7aym – hDDR2 kinase domain + inhibitor
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman