Fibroblast growth factor receptor 3D receptor

3D structures of fibroblast growth factor receptor

Updated on 03-July-2025

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• FGFR1
  • 8jqi – hFGFR1 + PLC gamma – human – Cryo EM
    
• FGFR1 tyrosine kinase domain (TKD) residues 458-765
  • 4uwy – hFGFR1 TKD
    
  • 1fgk, 3kxx, 3ky2, 4rwi, 5flf – hFGFR1 TKD (mutant)
    
  • 4wun, 5am6, 5ew8, 5o49, 5o4a, 6c1o, 6mzq, 6mzw, 8xlo, 8xlq, 8xz7, 8y22, 9cd5 – hFGFR1 TKD + inhibitor
    
  • 1agw, 1fgi, 2fgi, 3c4f, 3js2, 3rhx, 4f63, 4f64, 4f65, 3tt0, 4nk9, 4nka, 4nks, 5b7v, 5am7, 4rwj, 4rwk, 4rwl, 4uwb, 4uwc, 4zsa, 5uq0, 5vnd, 5ur1, 6c18, 6c19, 6c1b, 6c1c, 5z0s, 6agx, 6itj, 6nvl, 6p68, 6p69, 7ozb, 7ozd, 7ozf, 7ozy, 7wct, 7wcw, 7wcx – hFGFR1 TKD (mutant) + inhibitor
    
  • 8yki – hFGFR1 TKD + anti-cancer drug
    
  • 5zv2, 7wcl, 8jmz – hFGFR1 TKD (mutant) + anti-cancer drug
    
  • 3krj – hFGFR1 TKD residues 538-678, 753-922 (mutant) + inhibitor
    
  • 1xr0 – hFGFR1 residues 409-430 + FGFR signaling adaptor N terminal - NMR
    
  • 3gqi – hFGFR1 TKD (mutant) with PTR + ACP
    
  • 3gql – hFGFR1 TKD (mutant) + substrate
    
• FGFR1 ligand-binding domain (LBD) D1 residues 35-208
  • 2cr3 – hFGFR1 LBD D1 - NMR
    
  • 2ckn – FGFR1 LBD D1 – mouse - NMR
    
• FGFR1 LBD D1 complex with FGF
  • 5w59 – hFGFR1 LBD D1 + FGF9
    
• FGFR1 LBD D2,D3 residues 142-365 complex with FGF
  • 3ojv – hFGFR1 LBD D2,D3 (mutant) + hFGF1 - human
    
  • 1cvs – hFGFR1 LBD D2,D3 (mutant) + hFGF2 (mutant)
    
  • 1evt – hFGFR1 LBD D2,D3 + hFGF1
    
  • 1fq9 – hFGFR1 (mutant) LBD D2,D3 + hFGF2 (mutant) + HS
    
  • 5w21. 7ysh – hFGFR1 LBD D2,D3 + hFGF23 + klotho
    
• FGFR2
• FGFR2 tyrosine kinase domain 413-821
  • 1gjo, 1oec, 2psq – hFGFR2 TKD
    
  • 2pvy, 2pwl, 2py3, 2pz5, 2pzp, 2pzr, 2q0b, 4j95, 4j96, 4j97, 4j98, 4j99, 5ugx, 5uhn, 5ui0 – hFGFR2 TKD (mutant) + ACP
    
  • 5ugl – hFGFR2 TKD (mutant) + ANP
    
  • 3b2t – hFGFR2 TKD (mutant) + adenosine derivative
    
  • 2pvf – hFGFR2 TKD with PTR + ACP + substrate peptide
    
  • 3cly, 6v6q – hFGFR2 TKD (mutant) with PTR + ACP
    
  • 5eg3 – hFGFR2 TKD (mutant) with PTR + ACP + phospholipase C γ
    
  • 3ri1, 6lvk, 6lvl, 8e1x, 8h75, 8stg, 8u1f, 8w2x, 8w38, 8w3d – hFGFR2 TKD + inhibitor
    
  • 7kia, 7kie, 8swe, 9u3n – hFGFR2 TKD (mutant) + inhibitor
    
• FGFR2 ligand-binding domain 134-249
  • 3dar, 3caf, 3euu – hFGFR2 LBD D2 150-249
    
  • 8om6 – hFGFR2 LBD D2 (mutant)
    
  • 1wvz – hFGFR2 LBD D2 - NMR
    
  • 4wv1 – hFGFR2 LBD D2 + antibody
    
  • 6l4o – hFGFR2 LBD D2 (mutant) + API5
    
  • 4hwu – hFGFR2 LBD D1 45-127
    
• FGFR2 complex with FGF
  • 1e0o – hFGFR2 (mutant) LBD D2,D3 + hFGF1 (mutant) + HS
    
  • 3oj2, 3ojm – hFGFR2 (mutant) LBD D2,D3 + hFGF1
    
  • 1djs – hFGFR2 LBD D2,D3 (mutant) + hFGF1
    
  • 1ev2, 1ii4, 1iil – hFGFR2 LBD D2,D3 + hFGF2 (mutant)
    
  • 4j23 – hFGFR2 LBD D2,D3 (mutant) + hFGF2 (mutant) + inhibitor
    
  • 3cu1 – hFGFR2 LBD D2 + hFGF1
    
  • 2fdb – hFGFR2 LBD D2,D3 + hFGF8b
    
  • 1nun – hFGFR2 LBD D2,D3 + hFGF10
    
• FGFR3
  • 3grw – hFGFR3 LBD D2,D3 + antibody
    
  • 2lzl – hFGFR3 residues 357-399 – NMR
    
  • 4k33 – hFGFR3 TKD (mutant)
    
  • 6lvm, 7dhl, 8udt, 8udu, 8udv, 9cd7, 9d1x – hFGFR3 TKD + inhibitor
    
  • 6pnx – hFGFR3 TKD (mutant) + ACP
    
• FGFR3 complex with FGF
  • 1ry7 – hFGFR3 LBD + hFGF1
    
  • 7ysu – hFGFR3 LBD D2,D3 + hFGF23 + klotho – Cryo EM
    
• FGFR4
• FGFR4 tyrosine kinase domain
  • 4tye, 4tyg, 4tyi, 4tyj – hFGFR4 TKD
    
  • 4qqj, 4qqt – hFGFR4 TKD (mutant)
    
  • 5jkg, 5nwz, 5nud, 6nvg, 6nvh, 6nvi, 6nvj, 6nvk, 6v9c, 7dtz, 7f3m, 7v29, 7vjl, 7wct, 7ybo, 7yc1, 7yc3, 8w5c – hFGFR4 TKD + inhibitor
    
  • 7tyd – hFGFR4 TKD + protein inhibitor
    
  • 6yi8 – hFGFR4 TKD + drug
    
  • 5xff, 5xfj, 6iuo, 6iup, 6jpe, 6jpj, 7v29, 7wcw, 7wcx, 7ybp, 7ybx, 8kh6, 8kh7, 8kh8, 8kh9 – hFGFR4 TKD (mutant) + inhibitor
    
  • 4qrc, 4r6v, 4qqc, 4qq5, 4uxq, 4xcu – hFGFR4 TKD (mutant) + irreversible inhibitor
    
• FGFR4 LBD
  • 6j6y – hFGFR4 LBD D2 + antibody
    
  • 7n1j, 7tyd – hFGFR4 LBD D3 + binder
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel