Focal adhesion kinase 3D structures

3D Structures of focal adhesion kinase

Updated on 06-March-2023

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• Focal adhesion kinase 1 (FAK1)
• FAK1 targeting domain 891-1052
  • 1k04, 1k05, 3s9o, 2l6h, 2l6g, 2l6f – hFAK1 – human
    
  • 1ow6, 1ow7 - hFAK1 + paxillin LD4 motif
    
  • 1ow8 - hFAK1 + paxillin LD2 motif
    
  • 3b71 - hFAK1 + ADP + ATP
    
  • 1k40 – mFAK1 – mouse
    
  • 5f28 – mFAK1 + MEF2C
    
  • 1ktm, 1qvx, 1pv3 - cFAK1 – chicken – NMR
• FAK1 kinase domain 411-686
  • 1mp8 - hFAK1
    
  • 2etm, 3bz3, 4gu9, 4kab, 4k9y, 4i4e, 4i4f, 4k8a, 4gu6, 4brx, 4ebv, 4ebw, 3pxk, 4q9s, 6i8z - hFAK1 + inhibitor
    
  • 4kao - hFAK1 (mutant) + pyrazole derivative
    
  • 2ijm - hFAK1 + ADP + ATP
    
  • 4d4r, 4d4s, 4d4v, 4d4y, 4d55, 4d5h, 4d5k - cFAK1
    
  • 2j0l - cFAK1 phosphorylated
    
  • 2jkk, 2jkm, 2jko, 2jkq, 4d58, 6yoj, 6yq1, 6yr9, 6yt6, 6yvs, 6yvy, 6yxv - cFAK1 + pyrimidine derivative
    
  • 4c7t, 6gcr, 6gcw, 6gcx - cFAK1 + inhibitor
    
• FAK1 FERM domain 31-405
  • 4cye - hFAK1
    
  • 4ny0 - hFAK1 (mutant)
    
  • 2j0j, 2j0k, 2j0m - cFAK1 kinase + FERM domains
    
  • 2aeh, 2al6, 6cb0 - cFAK1
    
  • 3zdt - cFAK1 (mutant)
    
• FAK1 FAT domain 749-874
  • 7w7z, 7w8i, 7w9u - hFAK1
    
  • 6pw8 – hFAK1 + paxillin peptide
    
  • 6bz3 – mFAK1 + netrin receptor peptide
    
• FAK1 FERM+kinase domains 30-696
  • 6ty4 - hFAK1 + AMPPNP – Cryo EM
    
  • 6ty3 - cFAK1
    
• Focal adhesion kinase 2 (FAK2) See Pyk2 in Tyrosine kinase

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Michal Harel