Glucose 6-phosphate dehydrogenase

spinqualitylabelsall models Structure of glucose 6-phosphate dehydrogenase complex with glucose 6-phosphate and Ca+2 ion (green) (PDB code 1e77). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Glucose 6-phosphate dehydrogenase (G6PD) or 6-phosphogluconolactonase catalyzes the conversion of glucose 6-phosphate (G6P)to 6-phospho-glucono-1,5-lactone. G6PD uses NAPD as cofactor. G6PD is found in the cytoplasm and its function is protection against oxidative damage caused by metabolism. G6PD is part of the pentose phosphate cycle which is part of the cellular carbohydrate synthesis. See also G6PD (Hebrew). Disease G6PD deficiency is genetically recessive and predisposes toward hemolytic anemia. This disease is not fatal if the carrier maintains a suitable diet and uses appropriate drugs like corticsteroids. G6PD deficiency in red blood cells causes lack of NADPH which results in oxidative damage of the cell membrane and its rupture. Structural highlights G6PD active site contains predominantly charged residues Ca coordination site (PDB code 1e77), water molecules shown as red spheres.

3D structures of glucose 6-phosphate dehydrogenase

Updated on 10-July-2025

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• Glucose 6-phosphate dehydrogenase
  • G6PD (Hebrew) – hG6PD - human
    
  • 1e77, 1e7m, 1h93, 1h9b – LmG6PD (mutant) – Leuconostoc mesenteroides
    
  • 3e15 – G6PD – Plasmodium vivax
    
  • 3c8n – MtG6PD (mutant) – Mycobacterium tuberculosis
    
  • 6d23 – TcG6PD – Trypanosoma cruzi
    
  • 4lgv – G6PD – Mycobacterium avium
    
  • 5lxe – G6PD – Rhodococcus jostii
    
  • 7e6h – KlG6PD – Kluyveromyces lactis
    
  • 7zht – LdG6PD – Leishmania donovani
    
  • 7xhp – ZmG6PD – Zymomonas mobilis
    
  • 9emn – SyG6PD - Synechocystis – Cryo EM
    
• Glucose 6-phosphate dehydrogenase complex
  • 1qki, 2bh9, 6e08, 6e0j, 6jyu, 7zvd – hG6PD + NADP - human
    
  • 6e07, 6va0, 6va7, 6va8, 6va9, 6vaq – hG6PD (mutant) + NADP
    
  • 2bhl, 5ukw – hG6PD (mutant) + G6P
    
  • 6d24 – TcG6PD + G6P
    
  • 5aq1 – TcG6PD + G6P + NADP
    
  • 3b4y – MtG6PD (mutant) + coenzyme F420
    
  • 2dpg, 1h9a – LmG6PD (mutant) + NADP
    
  • 1h94 – LmG6PD (mutant) + NAD
    
  • 1e77 – LmG6PD (mutant) + G6P
    
  • 1e7y – LmG6PD (mutant) + G6P + NADP
    
  • 7e6i – KlG6PD + G6P
    
  • 7xhl – ZmG6PD + NADP derivative
    
  • 7zhu – LdG6PD + NADP
    
  • 7zhx, 7zhy – LdG6PD (mutant) + NADP
    
  • 7zhv – LdG6PD + G6P
    
  • 7zhw – LdG6PD + G6P + NADP
    
  • 7zhz – LdG6PD (mutant) + G6P + NADP
    
  • 9emm – SyG6PD + OpcA – Cryo EM
    

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