Gramicidin Channel in Lipid Bilayer
From Proteopedia
Jump to navigationJump to search
Two copies of the 15-amino-acid gramicidin peptide are shown here (restore initial scene) arranged as they are believed to be when they form a channel through a lipid bilayer membrane[1]. The shape of the protein is shown with tiny dots, inside of which is a ribbon backbone trace connecting the alpha carbon atoms of each amino acid chain.
- Show only the backbone of the gramicidin protein chains. The chains are covalently linked with dioxolane in this experiment (C, O)
- Show a slice of the lipid bilayer.
C, H, O, N, P
(Most hydrogen atoms are omitted.) - Show water. Notice how the hydrophobic lipid "tails" exclude water.
- Water passes through the channel.
- Show only water.
- Show only
2 phospholipids and 2 waters. C, H, O, N, P.
For an explanation of their structure, see the detailed tutorial, also disponible en español.
 |
|
| Remember to use the popup button and then resize the popup window to enlarge the molecular scenes. |
See Also
- A detailed explanation and tutorial about Lipid Bilayers and the Gramicidin Channel.
- This model in FirstGlance in Jmol. Be sure to click the Ligands+ and Water buttons!
- Lipids: structure and classification
- BioMolecular Explorer 3D, a resource for high school teachers that includes a section on gramicidin in a lipid bilayer.
- High school teachers' resources
- The Spanish version of this page: Canal de gramicidina en bicapa lipídica (Spanish)
- For additional information, see: Membrane Channels & Pumps
Notes
- The PDB file shown here, File:Gramicidin in bilayer.pdb.gz, was kindly provided by Serge Crouzy[1].
References
- ↑ 1.0 1.1 1.2 Crouzy S, Woolf TB, Roux B. A molecular dynamics study of gating in dioxolane-linked gramicidin A channels. Biophys J. 1994 Oct;67(4):1370-86. PMID:7529578 doi:https://dx.doi.org/10.1016/S0006-3495(94)80618-6
